Web12 de set. de 2024 · Hypoxia inducible factor (HIF) and mammalian target of rapamycin (mTOR) pathways orchestrate responses to oxygen and nutrient availability. These pathways are frequently dysregulated in cancer ... WebThe mTOR (mechanistic [previously called mammalian] target of rapamycin) is an atypical serine/threonine kinase, belonging to the PIKK (phosphoinositide kinase–related kinase) family. 1 – 6 It is an evolutionarily conserved protein that plays a central role in the regulation of cellular physiology, metabolism, and stress responses. 1 – 6.
mTOR- and HIF-1α-mediated aerobic glycolysis as metabolic basis for ...
Web9 de ago. de 2024 · The Akt inhibitor, wortmannin, could also inhibit the expression of HIF-1α at the protein, but not the mRNA level . mTOR is a hypoxia/nutrient sensor and a target of Akt during cell cycle regulation, glycogen metabolism and protein synthesis upon phosphorylation of its two main targets, eukaryotic initiation factor 4E-binding protein-1 … Web16 de jun. de 2014 · HIF-1α is potently induced by active mTOR mutants. To explore this mechanism further, we used cell line models allowing us to manipulate specific facets of mTORC1 signalling. church edicate for children
Hypoxia-inducible Factor 1α Is Regulated by the …
Web9 de jul. de 2015 · To prove if Akt/mTOR/HIF-1α axis is involved in elevated aerobic glycolysis in tamoxifen-resistant breast cancer cells, their phosphorylation status or expression levels were investigated by western blot analysis after knockdown of HK-2 or 3-BrPA treatment followed by 4-OHT treatment in three cell lines. WebTumors that form as a result of heightened mammalian target of rapamycin (mTOR) signaling are highly vascularized. This process of angiogenesis is regulated through hypoxia-inducible factor (HIF) … Web3 de jun. de 2024 · The inhibition experiment confirmed that hydroxytyrosol takes part in the expression of protein PI3K and p-mTOR. Conclusion. Hydroxytyrosol reduced the oxidative stress and resisted the inhibition of PI3K/AKT/mTOR-HIF-1 α signaling pathway caused by hypoxia, improved cell apoptosis, and ameliorated the antihypoxia ability of PC12 cells … church edgewater